In biotechnology, the rank and file are well-to-do.

Many of the highest-paying employers in the health-care sector—and the entire S&P 500—were biotech companies, according to an analysis by The Wall Street Journal of annual disclosures for hundreds of big U.S. companies as provided by MyLogIQ.

New Jersey-based Celgene Corp. , which sells a treatment of multiple myeloma, had the highest-paid median employee in the sector and S&P 500 at $263,237. Celgene was followed by Boston-based Vertex Pharmaceuticals Inc., VRTX 1.61% which makes treatments for cystic fibrosis and infectious diseases, paying its typical worker $232,178.

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